LncRNA PCAT1 activates SOX2 and suppresses radioimmune responses via regulating cGAS/STING signalling in non-small cell lung cancer.

Yanping GaoNannan ZhangZihang ZengQiuji WuXueping JiangShuying LiWenjie SunJianguo ZhangYangyi LiJiali LiFajian HeZhengrong HuangJinfang ZhangYan Gong Conghua Xie

Published in: Clinical and translational medicine (2022)

PCAT1/SOX2 axis promoted tumorigenesis and immunosuppression through inhibition of cGAS/STING signalling-mediated T-cell activation. Inhibition of PCAT1 and SOX2 synergised with radiotherapy to activate the immune response and could serve as potential therapeutic targets.

Keyphrases

transcription factor
stem cells
immune response
early stage
signaling pathway
radiation therapy
long non coding rna
toll like receptor
dendritic cells
human health
squamous cell carcinoma
risk assessment
long noncoding rna
inflammatory response
rectal cancer
innate immune