Evaluating the IgMi mouse as a novel tool to study B-cell biology.
Rinal SahputraJuan Carlos Yam-PucAri WaismanWerner MullerKathryn J ElsePublished in: European journal of immunology (2018)
The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.