Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults.
Jillian H HurstAlexander W McCumberJhoanna N AquinoJavier RodriguezSarah M HestonDebra J LugoAlexandre T RottaNicholas A TurnerTrevor S PfeifferThaddeus C GurleyM Anthony MoodyThomas N DennyJohn F RawlsJames S ClarkChristopher W WoodsMatthew S KellyPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
We identified interactive relationships between age and specific nasopharyngeal microbiome features that are associated with SARS-CoV-2 infection susceptibility and symptoms in children, adolescents, and young adults. Our data suggest that the upper respiratory microbiome may be a mechanism by which age influences SARS-CoV-2 susceptibility and illness severity.