Login / Signup

Low-density lipoprotein: a versatile nanoscale platform for targeted delivery.

Luyao DaiShuaijun LiQian HaoRuina ZhouHui ZhouWenxi LeiHuafeng KangHao WuYuanpei LiXiaobin Ma
Published in: Nanoscale advances (2023)
Low-density lipoprotein (LDL) is a small lipoprotein that plays a vital role in controlling lipid metabolism. LDL has a delicate nanostructure with unique physicochemical properties: superior payload capacity, long residence time in circulation, excellent biocompatibility, smaller size, and natural targeting. In recent decades, the superiority and feasibility of LDL particles as targeted delivery carriers have attracted much attention. In this review, we introduce the structure, composition, advantages, defects, and reconstruction of LDL delivery systems, summarize their research status and progress in targeted diagnosis and therapy, and finally look forward to the clinical application of LDL as an effective delivery vehicle.
Keyphrases
  • low density lipoprotein
  • cancer therapy
  • working memory
  • stem cells
  • mesenchymal stem cells
  • cell therapy
  • single molecule