Inaccurately Reported Statin Use Affects the Assessing of Lipid Profile Measures and Their Association with Coronary Artery Disease Risk.
Anna A IvanovaMichael S GardnerJennifer D KusovschiBryan A ParksDavid M SchieltzAkshay BarejaRobert W McGarrahWilliam E KrausZsuzsanna KuklenyikJames L PirkleJohn R BarrPublished in: Clinical chemistry (2024)
Our study uncovered prominent discrepancies between medication records and actual statin use measured by mass spectrometry. We showed that inaccurate statin use assessments may lead to overestimation and underestimation of LDL levels in statin user and nonuser categories, exaggerating the reverse epidemiology association between LDL levels and CAD diagnosis. Combining medication history and quantitative statin assay data can significantly improve the design, analysis, and interpretation of clinical and epidemiological studies.
Keyphrases
- coronary artery disease
- low density lipoprotein
- cardiovascular disease
- percutaneous coronary intervention
- cardiovascular events
- mass spectrometry
- coronary artery bypass grafting
- healthcare
- high throughput
- adverse drug
- emergency department
- heart failure
- electronic health record
- machine learning
- acute coronary syndrome
- aortic stenosis
- atrial fibrillation
- capillary electrophoresis
- data analysis