Profilin-1 negatively controls osteoclast migration by suppressing the protrusive structures based on branched actin filaments.
Shuhei KajikawaYoichi EzuraYayoi IzuKazuhisa NakashimaMasaki NodaAkira NifujiPublished in: Journal of bone and mineral metabolism (2022)
Our results indicated the causative involvement of the increased branched actin filament formation at least in part for their excessive migration. Our findings provide a mechanistic rationale for testing novel therapeutic approaches targeting branched actin filaments in osteolytic disorders.