Study of inner retinal neurodegeneration in Diabetes Mellitus using spectral domain optical coherence tomography.

There is a significant reduction in the GC-IPL thickness and the RNFL thickness in diabetes even before the onset of DR. The changes in both GC-IPL thickness and RNFL thickness are most pronounced after the onset of PDR. There is a strongly negative correlation between the minimum RNFL thickness with the severity of DR.