Functional neuromuscular impairment in severe intestinal dysmotility.

Diana GallegoCarolina MalageladaAnna AccarinoAlessandra GoriJuan Ramón MalageladaFernando Azpiroz Roberto De Giorgio Marcel Jiménez

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

Abnormalities of neuromuscular intestinal function are detected in vitro in severe intestinal dysmotility. However, consistent with the heterogeneity of the disease pathophysiology, functional impairment cannot be attributed to a single mechanism. Specifically, defects of purinergic neuromuscular transmission may have an important role in motility disorders of the gastrointestinal tract.

Keyphrases

early onset
single cell
biofilm formation
staphylococcus aureus
cystic fibrosis
pseudomonas aeruginosa