METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Fanpeng ZhaoYing XuShichao GaoLixia QinQuillan AustriaSandra L SiedlakKinga PajdzikQing DaiChuan HeWenzhang WangJames M O'DonnellBeisha TangXiongwei Zhu

Published in: Molecular neurodegeneration (2021)

Collectively, these data suggested that METTL3 reduction-mediated m6A dysregulation likely contributes to neurodegeneration in AD which may be a therapeutic target for AD.

Keyphrases

cell cycle
cell proliferation
electronic health record
cognitive decline
big data
nucleic acid
artificial intelligence