Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine.
Jonah A Padawer-CurryLindsay E VolkConstantine D MavroudisTiffany S KoVincent C MoranoDavid R BuschTami M RosenthalRichard W MelchiorBrandon C ShadeKellie L SchiavoTimothy W BooradyAlexander L SchmidtKristen N AndersenJake S BreimannJharna JahnaviKobina G Mensah-BrownArjun G YodhChristopher E MascioTodd J KilbaughDaniel J LichtBrian R WhiteWesley Boehs BakerPublished in: Pediatric research (2021)
Approximately half of the patients who survive neonatal heart surgery with cardiopulmonary bypass (CPB) experience neurodevelopmental delays. This preclinical investigation takes steps to elucidate and isolate potential perioperative risk factors of neurologic injury, such as impairment of cerebral autoregulation, associated with cardiac surgical procedures involving CPB. We demonstrate a method to characterize cerebral autoregulation during CPB pump flow changes in a neonatal swine model of cardiac surgery. Cerebral autoregulation was not altered in piglets that underwent deep hypothermic circulatory arrest (DHCA) or selective cerebral perfusion (SCP), but it was altered in piglets that underwent deep hypothermic CBP.
Keyphrases
- subarachnoid hemorrhage
- cerebral blood flow
- cardiac surgery
- risk factors
- cerebral ischemia
- brain injury
- heart failure
- acute kidney injury
- minimally invasive
- cell cycle
- stem cells
- left ventricular
- magnetic resonance imaging
- cell proliferation
- atrial fibrillation
- patients undergoing
- coronary artery bypass
- blood brain barrier
- coronary artery disease
- acute coronary syndrome
- climate change