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Structural Studies of Chikungunya Virus-Like Particles Complexed with Human Antibodies: Neutralization and Cell-to-Cell Transmission.

Jason PortaVidya Mangala PrasadCheng-I WangWataru AkahataLisa F P NgMichael G Rossmann
Published in: Journal of virology (2015)
Alphaviral infections are transmitted mainly by mosquitoes. Chikungunya virus (CHIKV), which belongs to the Alphavirus genus, has a wide distribution in the Old World that has expanded in recent years into the Americas. There are currently no vaccines or drugs against alphaviral infections. Therefore, a better understanding of CHIKV and its associated neutralizing antibodies will aid in the development of effective treatments.
Keyphrases
  • dengue virus
  • aedes aegypti
  • zika virus
  • single cell
  • cell therapy
  • endothelial cells
  • stem cells