Enantioselective Friedel-Crafts Alkylation of Furans with o -Quinone Methide Using a Chiral Oxazaborolidinium Ion Catalyst.
Yoon Sung ChoSeung Tae KimDo Hyun RyuPublished in: Organic letters (2022)
A chiral Lewis acid-catalyzed enantioselective Friedel-Crafts furan alkylation with in situ-generated o -quinone methides has been developed. In the presence of a chiral oxazaborolidinium ion catalyst, the reaction proceeded in high yield (up to 99%) with excellent enantioselectivity (up to >99% ee ).