MRI Clustering Reveals Three ALS Subtypes With Unique Neurodegeneration Patterns.
Harold H G TanHenk-Jan WestenengAbram D NitertKevin van VeenhuijzenJil M MeierHannelore K van der BurghMartine J E van ZandvoortMichael A van EsJan H VeldinkLeonard H van den BergPublished in: Annals of neurology (2022)
ALS can manifest itself in 3 main patterns of cerebral neurodegeneration, each associated with distinct clinical characteristics and cognitive profiles. Besides the pure motor and frontotemporal dementia (FTD)-like variants of ALS, a new neuroimaging phenotype has emerged, characterized by posterior cingulate, parietal, temporal, and cerebellar involvement. ANN NEUROL 2022;92:1030-1045.