Exendin-4 ameliorates tau hyperphosphorylation and cognitive impairment in type 2 diabetes through acting on Wnt/β-catenin/NeuroD1 pathway.
Xiaonan KangDan WangLu ZhangTeng HuangSiyue LiuXiaohui FengYaoyao GuoZiyin ZhangZhongjing WangHuihui RenGang YuanPublished in: Molecular medicine (Cambridge, Mass.) (2023)
Our study proposes that Ex-4 alleviates tau hyperphosphorylation and cognitive dysfunction by increasing Ins2-derived brain insulin through the Wnt/β-catenin/NeuroD1 signaling in T2D. And its also show new lights on part of the progress and mechanism on treatment targets for the DE in T2D.