Detection of prions in the urine of patients affected by sporadic Creutzfeldt-Jakob disease.
Sandra PritzkowFrank RamirezAdam LyonPaul E SchulzBrian ApplebyFabio ModaSantiago RamirezSilvio NotariPierluigi GambettiClaudio SotoPublished in: Annals of clinical and translational neurology (2023)
Our findings indicate that potentially infectious prions are secreted in urine of some sCJD patients, suggesting a possible risk for inter-individual transmission. Prion detection in urine might be used as a noninvasive preliminary screening test to detect sCJD.