The Relationship between Cancer and Paraoxonase 1.
Irma Martha Medina-DíazNéstor Ponce-RuízAurora Elizabeth Rojas-GarcíaJosé Francisco Zambrano-ZargozaYael Y Bernal-HernándezCyndia Azucena González-AriasBriscia Socorro Barrón-VivancoJosé Francisco Herrera-MorenoPublished in: Antioxidants (Basel, Switzerland) (2022)
Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The data suggest that PON1, oxidative stress, chronic inflammation, and cancer are closely linked. Certainly, the gene expression of PON1 will remain challenging to study. Therefore, targeting PON1, redox-sensitive pathways, and transcription factors promise prevention and therapy in the development of several diseases, including cancer.
Keyphrases
- papillary thyroid
- oxidative stress
- gene expression
- squamous cell
- cardiovascular disease
- transcription factor
- squamous cell carcinoma
- lymph node metastasis
- dna damage
- stem cells
- metabolic syndrome
- drug delivery
- big data
- coronary artery disease
- signaling pathway
- electronic health record
- subarachnoid hemorrhage
- cancer therapy
- heat shock
- drug induced