Molecular determinants of drug response in TNBC cell lines.

Nathan M MerrillEric J LachaczNathalie M VandecanPeter J UlintzLiwei BaoJohn P LloydJoel A YatesAki MorikawaSofia D MerajverMatthew B Soellner

Published in: Breast cancer research and treatment (2019)

These findings demonstrate an integrated method to identify biomarkers of drug efficacy in TNBC where DNA predictions correlate poorly with drug response. Our work outlines a framework for the identification of novel molecular determinants and optimal companion drugs for combination therapy based on these correlates.

Keyphrases

combination therapy
single molecule
adverse drug
drug induced
emergency department
cell free
bioinformatics analysis