Effective nebulization of interferon-γ using a novel vibrating mesh.
Louise SweeneyAlice P McCloskeyGerard HigginsJoanne M RamseySally-Ann CryanAlice P McCloskeyPublished in: Respiratory research (2019)
It is possible to nebulize IFN-γ effectively with vibrating mesh nebulizer devices without compromising its stability. The PDAP allows for generation of IFN-γ aerosols with improved aerodynamic properties thereby increasing its potential efficiency for lower respiratory tract deposition over current technology, whilst maintaining the integrity and bioactivity of IFN-γ. This delivery modality therefore offers a rational means of facilitating the clinical translation of inhaled IFN-γ.