Imaging Fibroblast Activation Protein Alpha Improves Diagnosis of Metastatic Prostate Cancer with Positron Emission Tomography.
Hallie M HintzJoseph P GallantDonald J Vander GriendIlsa M ColemanPeter S NelsonAaron M LeBeauPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Our study reveals FAP as a target for imaging the tumor microenvironment of prostate cancer. Validation of [89Zr]Zr-B12 IgG as a selective imaging probe for FAP-expressing tumors presents a new approach for noninvasive PET/CT imaging of mCRPC.