Association of the CFTR gene with asthma and airway mucus hypersecretion.

Astrid Crespo-LessmannSara BernalElisabeth Del RíoEster RojasCarlos Martínez-RiveraNuria MarinaAbel Pallarés-SanmartínSilvia PascualJuan Luis García-RiveroAlicia Padilla-GaloElena CurtoCarolina CisnerosJosé SerranoMontserrat BaigetVicente Plazanull null

Published in: PloS one (2021)

The results suggest that patients with asthma and with mucus hypersecretion (1) may have a different phenotype and disease mechanism produced by an intronic polymorphism in the CFTR gene (NM_000492.3:c.1680-870T>A), and (2) may have a poorer clinical outcome characterized by severe disease and poorer asthma control with a non-allergic inflammatory phenotype.

Keyphrases

lung function
allergic rhinitis
cystic fibrosis
chronic obstructive pulmonary disease
copy number
genome wide
oxidative stress
photodynamic therapy
early onset
air pollution
gene expression
atopic dermatitis