A scoping review of patient and public perspectives on cell and gene therapies.
Karen MacphersonOlalekan Lee AiyegbusiLauren ElstonSusan MylesJennifer WashingtonNisha SungumMark BriggsPhilip Noel NewsomeMelanie Jane CalvertPublished in: Regenerative medicine (2021)
Aim: The development and introduction of cell and gene therapies presents complex social and economic issues. Fully addressing these challenges requires engagement with patients and the public. Materials & methods: A systematically conducted scoping review was undertaken to gauge current patient and public knowledge and perspectives, and as such inform requirements for future research, education and engagement activities. Results: A heterogeneous collection of 35 studies were identified. Levels of knowledge among patients and the public were extremely variable. Studies indicated general acceptance of therapies. Conclusion: The review identified the need for tailored educational activities, and in particular the importance of addressing misconceptions. There is also a need for robust qualitative research considering perspectives on current and forthcoming licensed therapies.
Keyphrases
- healthcare
- mental health
- end stage renal disease
- single cell
- cell therapy
- case report
- social media
- ejection fraction
- chronic kidney disease
- newly diagnosed
- genome wide
- copy number
- prognostic factors
- systematic review
- case control
- quality improvement
- adverse drug
- genome wide identification
- bone marrow
- transcription factor
- electronic health record