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Genetic risk factors of Alzheimer's Disease disrupt resting-state functional connectivity in cognitively intact young individuals.

Ludmila KucikovaJianmin ZengCarlos Muñoz-NeiraGraciela Muniz-TerreraWeijie HuangSarah GregoryCraig RitchieJohn O'BrienLi Su
Published in: Journal of neurology (2023)
Our findings indicate that APOEe4 and MAPTA alleles modulate brain functional connectivity in the brain regions within the DMN in cognitively intact young adults. APOEe4 carriers also showed a link between connectivity and cognition.
Keyphrases
  • resting state
  • functional connectivity
  • cognitive decline
  • mild cognitive impairment
  • young adults
  • risk factors
  • white matter
  • genome wide
  • multiple sclerosis
  • middle aged
  • copy number
  • blood brain barrier