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Hyperammonemic Encephalopathy in a Patient with Pancreatic Neuroendocrine Tumor and Portosystemic Shunt.

Marcel ZorgdragerFrans J C CuperusRobbert J de Haas
Published in: Diagnostics (Basel, Switzerland) (2023)
Hyperammonemia can lead to encephalopathy and may be accompanied by a diagnostic dilemma. Imaging as well as biochemical analyses are the cornerstone for identifying possible underlying causes such as severe liver disease or urea cycle defect. We report a case of a patient that presented with neurological deficits based on hyperammonemia in the presence of a large pancreatic neuroendocrine tumor (PNET) and portosystemic shunts in the liver. Prior cases are rather scarce, and the exact mechanism is not fully understood. The case illustrates the added value of a multimodality imaging approach in patients presenting with hyperammonemia-induced encephalopathy.
Keyphrases
  • early onset
  • high resolution
  • case report
  • drug induced
  • high glucose
  • pulmonary artery
  • density functional theory
  • fluorescence imaging
  • oxidative stress
  • molecular dynamics
  • stress induced