Age of Pediatric Patients Affects Delayed Chemotherapy-Induced Vomiting.
Hangyan ZhaoJianbin WengWujie ShiLuping PanChao LinNing WangJihua ZhuZhipeng ShenPublished in: Clinical pediatrics (2023)
The purpose of this study was to investigate the risk factors for delayed chemotherapy-induced vomiting (DCIV) in pediatric oncology patients. We collected data on pediatric patients from a tertiary care pediatric hospital in an Asian urban center. We analyzed the risk factors for DCIV in patients by univariate analysis and logistic regression. Patients were grouped according to age by the Youden index, and differences in clinical features between the high-risk and low-risk groups were calculated. In the univariate analysis, the number of chemotherapy days, pH, and blood glucose levels were significantly associated with DCIV. In the logistic regression analysis, patient age was an independent risk factor (odds ratio [OR] = 1.013, 95% confidence interval [CI] = 1.005-1.021, P = .002). Children in the high-risk group had a higher grade of vomiting ( P < .05). Age is an important risk factor for DCIV in pediatric patients, with older children tending to experience more frequent and more severe vomiting.
Keyphrases
- chemotherapy induced
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- blood glucose
- prognostic factors
- healthcare
- risk factors
- emergency department
- squamous cell carcinoma
- peritoneal dialysis
- physical activity
- insulin resistance
- radiation therapy
- patient reported outcomes
- early onset
- locally advanced
- weight loss
- rectal cancer
- middle aged
- community dwelling
- adverse drug