circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.

Wei GaoHuina GuoMin NiuXiwang ZhengYuliang ZhangXuting XueYunfeng BoXiaoya GuanZhongxun LiYujia GuoLong HeYu ZhangLi LiJimin CaoYongyan Wu

Published in: Molecular cancer (2020)

Our study reveals that the novel autophagy-suppressive circPARD3 promotes LSCC progression and chemoresistance through the PRKCI-Akt-mTOR pathway, providing new insights into circRNA-mediated autophagy regulation and potential biomarker and target for LSCC treatment.

Keyphrases

signaling pathway
cell proliferation
cell death
squamous cell carcinoma
endoplasmic reticulum stress
oxidative stress
radiation therapy
locally advanced
replacement therapy
smoking cessation