Riluzole synergizes with paclitaxel to inhibit cell growth and induce apoptosis in triple-negative breast cancer.

Cecilia L SpeyerMiriam A BukhshWaris S JafryRachael E SextonSudeshna BandyopadhyayDavid H Gorski

Published in: Breast cancer research and treatment (2017)

All TNBC cells tested responded synergistically to riluzole and paclitaxel strongly suggesting the usefulness of this combinatorial treatment strategy in TNBC, especially for patients whose tumors are relatively resistant to paclitaxel.

Keyphrases

cell cycle arrest
end stage renal disease
induced apoptosis
chronic kidney disease
ejection fraction
newly diagnosed
endoplasmic reticulum stress
oxidative stress
signaling pathway
pi k akt
chemotherapy induced
patient reported