Repair abilities of mouse autologous adipose-derived stem cells and ShakeGel™3D complex local injection with intrauterine adhesion by BMP7-Smad5 signaling pathway activation.

Yun-Xia ZhaoShao-Rong ChenQiao-Yi HuangWei-Can ChenTian XiaYan-Chuan ShiHong-Zhi GaoQi-Yang ShiShu Lin

Published in: Stem cell research & therapy (2021)

Autologous ADSCs can be used in combination with ShakeGel™3D to maintain functionality and create a viable three-dimensional growth environment. The combined transplantation of autologous ADSCs and ShakeGel™3D promotes the recovery of damaged endometrial tissue by increasing BMP7-Smad5 signal transduction, resulting in endometrium thickening, increased number of glands, and decreased fibrosis, leading to restoration of partial fertility.

Keyphrases

cell therapy
epithelial mesenchymal transition
bone marrow
mesenchymal stem cells
signaling pathway
platelet rich plasma
transforming growth factor
stem cells
endometrial cancer
staphylococcus aureus
induced apoptosis
pseudomonas aeruginosa
young adults
biofilm formation
cell migration