DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism.

Lilong GuoTyler BeckDiana FulmerSandra Ramos-OrtizJaniece GloverChristina WangKelsey MooreCortney GensemerJordan MorningstarReece MooreJean-Jacques SchottThierry Le TourneauNatalie KorenRussell A Norris

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)

Dzip1 functions to restrain β-catenin signaling through a CBY1 linker during cardiac development. Loss of these interactions results in increased nuclear β-catenin/Lef1 and excess MMP2 production, which correlates with developmental and postnatal changes in ECM and generation of a myxomatous phenotype.

Keyphrases

epithelial mesenchymal transition
left ventricular
cell proliferation
mitral valve
preterm infants
aortic valve
signaling pathway
atrial fibrillation