Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition.
Mengyi ZhuLijuan WangWei ZhangZhiwen LiuMuhammad AliMuhammad ImtiazJing HePublished in: Journal of natural products (2020)
The diisonitrile copper chelator SF2768 biosynthesized by Streptomyces thioluteus functions as a chalkophore that transports extracellular copper into producer cells in a complexed form. It was demonstrated that the treatment of eight bacteria, including Bacillus subtilis and Acinetobacter baumannii, with SF2768 led to a moderate growth inhibition which is associated with an increased level of reactive oxygen species (ROS). In addition, SF2768 and its diisonitrile analogues proved to be effective tyrosinase inhibitors. Three new analogues, SF2768 I, K, and L, were identified by detailed spectroscopic analysis.
Keyphrases
- reactive oxygen species
- acinetobacter baumannii
- molecular docking
- bacillus subtilis
- multidrug resistant
- drug resistant
- induced apoptosis
- pseudomonas aeruginosa
- cell cycle arrest
- oxidative stress
- dna damage
- high intensity
- structure activity relationship
- oxide nanoparticles
- endoplasmic reticulum stress
- cell proliferation
- cystic fibrosis
- silver nanoparticles
- signaling pathway
- replacement therapy
- data analysis