Association study of copy number variation in BMP8A gene with the risk of ankylosing spondylitis in Iranian population.
Sara ShahbaReza Jafari ShakibAhmadreza JamshidiMahdi VojdanianMaryam AkhtariSaeed AslaniShiva PoursaniIraj NikokarMahdi MahmoudiPublished in: Journal of cellular biochemistry (2018)
Although BMP8A gene expression was downregulated in patients with AS, its copy number could not affect the transcript level of BMP8A gene in PBMCs and was not associated with susceptibility to AS in Iranian population. BMP8a may take into account as an indicator of bone formation process in AS, but it seems that mechanisms other than CNV may regulate this protein.