Natural History of Patients With Ischemia and No Obstructive Coronary Artery Disease: The CIAO-ISCHEMIA Study.
Harmony R ReynoldsMichael H PicardJohn A SpertusJesus PeteiroJose Luis Lopez SendonRoxy SeniorMohammad C El-HajjarJelena CelutkieneMichael David ShapiroPatricia A PellikkaDennis F KunichoffRebecca AnthopolosKhaled AlfakihKhaled Abdul-NourMichel KhouriLeonid BershteinMark De BelderKian Keong PohJohn F BeltrameJames K MinJerome L FlegYi LiDavid J MaronJudith S HochmanPublished in: Circulation (2021)
Improvement in ischemia and angina were common in INOCA but not correlated. Our INOCA cohort had a degree of inducible wall motion abnormalities similar to concurrently enrolled ISCHEMIA participants with obstructive coronary artery disease. Our results highlight the complex nature of INOCA pathophysiology and the multifactorial nature of angina. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02347215.