Correlation between molar activity, injection mass and uptake of the PARP targeting radiotracer [ 18 F]olaparib in mouse models of glioma.
Chung Ying ChanSamantha L HopkinsFlorian GuibbalAnna PacelliJulia Baguña TorresMichael MosleyDoreen LauPatrick IseneggerZijun ChenThomas C WilsonGemma DiasRebekka HuetingVéronique GouverneurBart CornelissenPublished in: EJNMMI research (2022)
F]olaparib has significant effects on tumour uptake. Moderate injected masses of PARP inhibitor-derived radiopharmaceuticals may lead to improved relative tumour uptake and tumour-to-background ratio for cancer diagnosis and radionuclide therapy.