DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRAS G12C -mutant cancer.

Li-Wen ChiouChien-Hui ChanYu-Ling JhuangChing-Yao YangYung-Ming Jeng

Published in: Journal of biomedical science (2023)

We elucidated the mechanisms underlying the sotorasib addiction of cancer cells. Sotorasib addiction appears to be mediated through MAPK pathway hyperactivity, DNA damage, replication stress, and mitotic catastrophe. Moreover, we devised a therapeutic strategy involving a type I BRAF inhibitor to strengthen the effects of sotorasib addiction; this strategy may provide clinical benefit for patients with cancer.

Keyphrases

dna damage
wild type
oxidative stress
cell cycle
signaling pathway
papillary thyroid
squamous cell carcinoma
cell proliferation