Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury.

Jing LiuSanjeev KumarAndreas HeinzlMichael GaoJinjin GuoGregory F AlvaradoRoman Reindl-SchwaighoferA Michaela KrautzbergerPietro E CippàJill McMahonRainer OberbauerAndrew P McMahon

Published in: Journal of the American Society of Nephrology : JASN (2020)

Gdf15 contributes to an early acting, renoprotective injury response, modifying immune cell actions. The data support further investigation in clinical model systems of the potential benefit from GDF15 administration in situations in which some level of tubular injury is inevitable, such as following a kidney transplant.

Keyphrases

ischemia reperfusion injury
acute kidney injury
oxidative stress
electronic health record
diabetic nephropathy
big data
machine learning
human health
risk assessment
artificial intelligence
data analysis