Palladium-Catalyzed Cascade Allylative Dicarbofunctionalization of Aryl Phenol-Tethered Alkynes with Allyl Iodides: Synthesis of Skipped Dienes.

A palladium-catalyzed cascade allylative dicarbofunctionalization of aryl phenol-tethered alkynes with allyl iodides is described. A series of polysubstituted spirocyclo-containing skipped dienes with an all-carbon tetrasubstituted alkene unit are synthesized through this convenient process. The cascade reaction proceeds selectively through dearomative C-allylation instead of O-allylation of aryl phenols.