Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection.
Dan NieYue HuZhou ChenMingkai LiZheng HouXiaoxing LuoXinggang MaoXiao-Yan XuePublished in: Journal of biomedical science (2020)
Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli (E. coli) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii. In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target.
Keyphrases
- acinetobacter baumannii
- pseudomonas aeruginosa
- biofilm formation
- multidrug resistant
- escherichia coli
- drug resistant
- cystic fibrosis
- candida albicans
- staphylococcus aureus
- klebsiella pneumoniae
- single cell
- cell therapy
- stem cells
- human health
- risk assessment
- mesenchymal stem cells
- bone marrow
- antimicrobial resistance