Characterizing White Matter in Huntington's Disease.
Sarah GregoryEileanoir JohnsonLauren M ByrneFilipe Brogueira RodriguesAlexandra HendersonJohn MossDavid ThomasHui ZhangEnrico De VitaSarah J TabriziGeraint ReesRachael I ScahillEdward J WildPublished in: Movement disorders clinical practice (2019)
Collectively, these findings present a more complete characterization of HD-related microstructural brain changes. The correlation between reduced fractional anisotropy, increased axonal orientation, and biofluid markers suggest that axonal breakdown is associated with increased WM degeneration, whereas higher quantitative T2 signal and lower myelin-contrast may indicate a process of demyelination limited to the striatum.