Circulating Cell-Free Mitochondrial DNA in Pregnancy.

Jessica L BradshawSpencer C CushenNicole R PhillipsStyliani Goulopoulou

Published in: Physiology (Bethesda, Md.) (2022)

Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.

Keyphrases

mitochondrial dna
cell free
pregnancy outcomes
immune response
copy number
pregnant women
circulating tumor
single cell
cell therapy
dendritic cells
toll like receptor
risk factors
genome wide
gene expression
stem cells
emergency department
inflammatory response
mesenchymal stem cells
adverse drug