Increased Toll-like Receptor-MyD88-NFκB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder.

Ryan P VetrenoLiya QinLeon G ColemanFulton T Crews

Published in: Alcoholism, clinical and experimental research (2021)

These data implicate the induction of HMGB1-TLR-MyD88-NFκB cascades through coordinated glial and neuronal signaling as contributors to the neurodegeneration seen in the postmortem human OFC of individuals with AUD.

Keyphrases

toll like receptor
nuclear factor
alcohol use disorder
inflammatory response
lps induced
signaling pathway
immune response
endothelial cells
pi k akt
oxidative stress
electronic health record
big data
neuropathic pain
spinal cord
cell proliferation
spinal cord injury
deep learning
cerebral ischemia