Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi.
Anna KoudrinaCeline ChartrandGreg O CronJonathan O'BrienEve C TsaiMaria C DeRosaPublished in: Chemical communications (Cambridge, England) (2022)
Targeting of molecular constituents of thrombi with aptamer functionalized core-shell nanoparticles (CSN) allowed for high resolution clot delineation in T2-weighted magnetic resonance imaging. Meanwhile, the gold-coating demonstrated sufficient contrast capabilities in computed tomography (1697 HU μM -1 ). This targeted CSN formulation could allow for precise imaging of blood clots at low nanomolar concentrations.
Keyphrases
- high resolution
- magnetic resonance imaging
- computed tomography
- contrast enhanced
- cancer therapy
- iron oxide nanoparticles
- magnetic resonance
- gold nanoparticles
- quantum dots
- drug delivery
- sensitive detection
- positron emission tomography
- mass spectrometry
- magnetic nanoparticles
- silver nanoparticles
- diffusion weighted imaging
- high speed
- network analysis
- image quality