Association of Multiple Plasma Biomarker Concentrations with Progression of Prevalent Diabetic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.
Sarah J SchraubenHaochang ShouXiaoming ZhangAmanda Hyre AndersonJoseph V BonventreJing ChenSteven G CocaSusan L FurthJason H GreenbergOrlando M GutiérrezJoachim H IxJames P LashChirag R ParikhCasey M RebholzVenkata SabbisettiMark J SarnakMichael G ShlipakSushrut S WaikarPaul L KimmelRamachandran S VasanHarold I FeldmanJeffrey R Schellingnull nullPublished in: Journal of the American Society of Nephrology : JASN (2020)
Higher plasma levels of KIM-1, TNFR-1, TNFR-2, MCP-1, suPAR, and YKL-40 were associated with increased risk of progression of diabetic kidney disease; TNFR-2 had the highest risk after accounting for the other biomarkers. These findings validate previous literature on TNFR-1, TNFR-2, and KIM-1 in patients with prevalent CKD and provide new insights into the influence of suPAR and YKL-40 as plasma biomarkers that require validation.