Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps.

Julie A PoposkiAiko I KlinglerBruce K TanPejman SorooshHomayon BanieGavin LewisKathryn E HulseWhitney W StevensAnju T PetersLeslie C GrammerRobert P SchleimerKevin C WelchStephanie S SmithDavid B ConleyJoseph R RavivJames G KarrasOmid AkbariRobert C KernAtsushi Kato

Published in: Immunity, inflammation and disease (2017)

These results suggest that ILC2 are not only elevated but also activated in CRSwNP in vivo and that ILC2 may play important roles in the type 2 inflammation in CRSwNP.

Keyphrases

chronic rhinosinusitis
induced apoptosis
oxidative stress
cell cycle arrest
nk cells
endoplasmic reticulum stress
cell death