Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis.
Dennis G MoledinaF Perry WilsonLidiya KukovaWassim ObeidRandy LucianoMichael KupermanGilbert W MoeckelMichael KashgarianMark A PerazellaLloyd G CantleyChirag R ParikhPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021)
Urine IL-9 was associated with lower 6 m-eGFR only in participants not treated with corticosteroids. Corticosteroid use was associated with higher 6 m-eGFR in those with high urine IL-9. These findings provide a framework for IL-9-guided clinical trials to test efficacy of immunosuppressive therapy in patients with AIN.