Ion mobility resolved photo-fragmentation to discriminate protomers.
Chang Min ChoiAlexander KuleszaSteven DalyLuke MacAleeseRodolphe AntoinePhilippe DugourdFabien ChirotPublished in: Rapid communications in mass spectrometry : RCM (2018)
We show that, even if precise structure assignment based on molecular modeling is in principle difficult for large biomolecular assemblies, the combination of photo-fragmentation and IMS can help to identify the signature of protomer co-existence for a population of biomolecular ions in the gas phase. Such spectroscopic data are particularly suitable to follow conformational changes.