FoxO1 knockdown inhibits RANKL-induced osteoclastogenesis by blocking NLRP3 inflammasome activation.

Zhanqi WangWenxin LuoGuorui ZhangHaiyun LiFeng ZhouDongyang WangXuan FengYi Xiong Yingying Wu

Published in: Oral diseases (2023)

FoxO1 knockdown contributed to the inhibition of osteoclastogenesis by effectively suppressing NF-κB signaling and NLRP3 inflammasome activation. This prospective study reveals the role of FoxO1 in mediating osteoclastogenesis and provides a viable therapeutic target for periodontitis treatment.

Keyphrases

nlrp inflammasome
signaling pathway
pi k akt
lps induced
bone loss
transcription factor
inflammatory response
high glucose
diabetic rats
cell proliferation
replacement therapy