Comparing echocardiographic characteristics in genotype positive-phenotype positive hypertrophic cardiomyopathy and hypertensive left ventricular hypertrophy.
Angelo de la RosaMaulin ShahTakahiro ShiotaRobert SiegelFlorian RaderPublished in: European heart journal. Cardiovascular Imaging (2021)
Gene-positive HCM, compared to hypertensive LVH, is characterized by more advanced diastolic dysfunction and larger LA size. Gene-positive HCM patients with concomitant HTN had greater LV mass, more severe LVH, and more abnormal GLS, suggesting HTN may negatively affect the progression of myocardial dysfunction in genetic HCM. LVH out-of-proportion to pressure burden in HTN patients should raise suspicion of underlying genetic HCM.
Keyphrases
- hypertrophic cardiomyopathy
- left ventricular
- cardiac resynchronization therapy
- genome wide
- acute myocardial infarction
- heart failure
- left atrial
- copy number
- mitral valve
- blood pressure
- aortic stenosis
- ejection fraction
- oxidative stress
- end stage renal disease
- newly diagnosed
- prognostic factors
- dna methylation
- coronary artery disease
- early onset
- transcription factor
- genome wide identification
- risk factors