Most Early-Treated Children With Perinatally Acquired HIV Have Preserved Lung Function at School Age.
Engi F AttiaHellen MoraaElizabeth Maleche-ObimboDalton WamalwaLaurén A GómezSarah RylanceRumbidzayi VundlaRashida A FerrandCatherine J KarrGrace C John-StewartSarah F Benki-NugentPublished in: Journal of acquired immune deficiency syndromes (1999) (2022)
Most of the children with PHIV who initiated ART at age 12 months or younger had normal spirometry, suggesting that ART in infancy preserved lung function. However, 13% had abnormal spirometry despite early ART. Modifiable factors were associated with impaired lung function, providing potential targets for interventions to prevent chronic lung disease.