A PET Imaging Strategy for Interrogating Target Engagement and Oncogene Status in Pancreatic Cancer.

Kelly E HenryMegan M DacekThomas R DillingJonathan D CaenIan L FoxKenneth W Bayles Jason S Lewis

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Our study demonstrates that [89Zr]Zr-Tf is a valuable tool to noninvasively assess oncogene status and target engagement of small-molecule inhibitors downstream of oncogenic KRAS, allowing a quantitative assessment of drug delivery.

Keyphrases

pet imaging
small molecule
drug delivery
social media
positron emission tomography
protein protein