Macrophage functions in wound healing.
Małgorzata KlocRafik M GhobrialJarek WosikAneta LewickaSławomir LewickiJacek Z KubiakPublished in: Journal of tissue engineering and regenerative medicine (2018)
Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.