Cancer-associated fibroblasts affect breast cancer cell gene expression, invasion and angiogenesis.

Noemi EiroLucía GonzálezAnxo Martínez-OrdoñezBelen Fernandez-GarciaLuis O GonzálezSandra CidFrancisco DominguezRomán Perez-FernandezFrancisco J Vizoso

Published in: Cellular oncology (Dordrecht) (2018)

Our data indicate that tumor-derived CAFs can induce up-regulation of genes involved in breast cancer progression. Our data additionally indicate that CAFs, especially those derived from MMP11+ MIC tumors, can promote breast cancer cell invasion and angiogenesis.

Keyphrases

gene expression
endothelial cells
electronic health record
vascular endothelial growth factor
big data
dna methylation
single cell
stem cells
cell therapy
machine learning
mesenchymal stem cells
young adults
bone marrow
deep learning
childhood cancer